Humanum BCR-ABL Fusion Gene Mutatio
Product nomen
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutatio Detection Kit (Fluorescens PCR)
Epidemiologia
Myelogenousleukemia chronica (CML) est malignus morbus clonalis cellae caulis hematopoieticae.Plus quam 95% of CML aegroti Philadelphiam chromosomatum (Ph) in suis cellulis sanguineis portant.Praedominantis pathogenesis CML haec est: Fusio gene BCR-ABL formatur per translocationem inter abl proto-oncogene (Abelson murinam leukemia viralem oncogene homologum 1) chromosomatis longi brachii 9 (9q34) et regionis botri rupturae ( BCR) gene chromosomatis brachii longi 22 (22q11);Fusio interdum ab hoc gena enodata tyrosinam kinasem (TK) activitatem habet, et amni ejus vias significativas (ut RAS, PI3K, JAK/STAT) promovet ad divisionem cellam promovendam et apoptosin cellam inhibet, cellulas faciens maligne proliferate ac per hoc causando Eventum CML.BCR-ABL unus ex indicibus diagnosticis magni momenti CML.In dynamica mutatione sui gradus transcripti certa indicator prognosticorum iudicium de leukemia et adhiberi potest ad recursum leukemia post curationem praedicere.
Channel
| FAM | BCR-ABL fusionem gene |
| VIC/HEX | Internum Imperium |
Technical Parameters
| Repono | Liquid: ≤-18℃ In tenebris |
| Fasciae vita | Liquid: 9 months |
| Specimen Type | Medulla ossis exempla |
| LoD | 1000 Copies/mL |
| Specification
| Nulla crux reactivitas cum aliis generum fusione TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, PML-RARa |
| Applicabilis Instrumenta | Acta Biosystems (VII)D Real-time PCR Systems Acta Biosystems (VII)D Fast Verus-Tempus PCR Systems QuantStudio® 5 Real-Time PCR Systems SLAN-96P Real-time PCR Systems LightCycler®480 Real-time PCR systema LineGene 9600 Plus Real-time PCR Detection System MA-6000 Real-time Quantitatis Thermal Cycler BioRad CFX96 Real-time PCR System BioRad CFX Opus 96 Real-time PCR System |
