Human CYP2C19 Gene Polymorphismus
Product nomen
HWTS-GE012A-Humanum CYP2C19 Gene Polymorphismus Deprehensio Kit (Fluorescens PCR)
Testimonium
CE
Epidemiologia
CYP2C19 una e maximis medicamentis metabolizationis enzymes in familia CYP450 est.Multae subiectae endogenae et circa 2% medicamenta clinica per CYP2C19 metabobilia sunt, sicut metabolismi antiplateletae aggregationis inhibitores (velut clopidogrel), sentinae inhibitores (omeprazole), anticonvulsantes, etc. CYP2C19 polymorphismi generum differentias habent in facultate metabolizationis. affinis medicinae.Haec puncta mutationum *2 (rs4244285) et *3 (rs4986893) causant detrimentum enzyme activitatis in CYP2C19 gene et debilitate substrati facultatis metabolicae, et sanguinem retrahitur auge, ut motus medicamentorum adversarum causat ad sanguinis defectus.*17 (rs12248560) enzyme activitatem CYP2C19 gene, metabolitae activae productionem augere potuit, et aggregationem inhibitionis laminae augere et periculum sanguinis augere.Pro homine lento metabolismi medicamentorum, normales doses diu graves toxici et effectus laterales facient: maxime damnum iecoris, damnum systematis hematopoieticum, systematis nervosi centralis damnum, etc., quae in gravibus casibus ad mortem ducere possunt.Secundum singulas differentias metabolismi medicamento respondente, plerumque in quattuor phaenotypa dividitur, nempe metabolismum ultra-celerium (UM, 17/*17,*1/*17), metabolismi ieiunium (RM, *1/*1 ) metabolismus intermedius (IM, *1/*2, *1/*3), metabolismus tardus (PM, *2/*2, *2/*3, *3/*3).
Channel
| FAM | CYP2C19*2 |
| CY5 | CYP2C9*3 |
| ROX | CYP2C19*17 |
| VIC/HEX | IC |
Technical Parameters
| Repono | Liquid: ≤-18℃ |
| Fasciae vita | XII mensibus |
| Specimen Type | Nova EDTA anticoagulata sanguine |
| CV | ≤5.0% |
| LoD | 1.0ng/μL |
| Specification | Nulla crux-reactivity cum aliis sequentiis maxime consistentibus (CYP2C9 gene) in genome humano.Mutationes CYP2C19*23, CYP2C19*24 et CYP2C19*25 situs extra detectionem range huius ornamenti nullum effectum habent in deprehensione huius ornamenti effectum. |
| Applicabilis Instrumenta | Acta Biosystems (VII)D Real-time PCR Systems Acta Biosystems (VII)D Fast Verus-Tempus PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-time PCR Systems LightCycler®480 Real-time PCR systema LineGene 9600 Plus Real-time PCR Detection System MA-6000 Real-time Quantitatis Thermal Cycler BioRad CFX96 Real-time PCR System BioRad CFX Opus 96 Real-time PCR System |
Opus O
Commendatur extraction iodo:Macro & Micro-test Viralis DNA/RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) et Macro & Micro-test Automatic Acidum Nucleicum Extractor (HWTS-3006).
