Human ROS1 Fusion Gene Mutation
Product nomen
HWTS-TM009-Human ROS1 Fusion Gene Mutatio Detection Kit (Fluorescens PCR)
Testimonium
CE
Epidemiologia
ROS1 tyrosinum transmembranum kinase receptoris familiae insulinae est.Fusio gene ROS1 confirmata est sicut alia magna non parva cellula pulmonis cancri agitator gene.Ut repraesentativum novae subtypi hypotheticae unicae, incidentia gene fusionis ROS1 in NSCLC Circa 1% ad 2% ROS1 maxime patitur conversionem gene in suis exons 32, 34, 35 et 36. Postea cum genesis conglutinantur ut CD74; EZR, SLC34A2, SDC4, perget ad regionem kinasim ROS1 tyrosinam excitandam.ROS1 kinase enorme excitari potest amni movere vias significans vias ut RAS/MAPK/ERK, PI3K/Akt/mTOR, et JAK3/STAT3, participando multiplicationem, differentiam et metastasim cellularum tumoris et cancer causantis.Inter confusiones ROS1, CD74-ROS1 rationes circiter 42%, EZR rationem circiter 15%, SLC34A2 rationem circiter 12%, et SDC4 rationem circiter 7%.Studia docuerunt ATP situs catalytici domain ROS1 kinasi et ATP ligandi situm ALK kinasi habere homologiam usque ad 77%, ita ALK tyrosinum kinasum parvae moleculi inhibitoris crizotinib et sic porro effectum curativum manifestum habent. in curatione NSCLC cum fusione mutationis ROS1.Ergo deprehensio mutationum ROS1 fusione praemissa est et fundamentum ad usum medicamentorum crizotinib dirigendum.
Channel
| FAM | Reactionem Buffer 1, 2, 3 et 4 |
| VIC(HEX) | Reactionem Buffer IV " |
Technical Parameters
| Repono | ≤-18℃ |
| Fasciae vita | IX mensibus |
| Specimen Type | paraffin-embedded vitiatam TEXTUS vel divisa exempla |
| CV | -5.0% |
| Ct | ≤38 |
| LoD | Hoc ornamentum fusionis mutationum quam infimae 20 exemplaribus deprehendere potest. |
| Instrumenta applicabilia: | Acta Biosystems (VII)D Real-time PCR SystemsActa Biosystems (VII)D Fast Verus-Tempus PCR Systems SLAN ®-96P Real-time PCR Systems QuantStudio™ 5 Real-Time PCR Systems LightCycler®480 Real-time PCR systema LineGene 9600 Plus Real-time PCR Detection System MA-6000 Real-time Quantitatis Thermal Cycler BioRad CFX96 Real-time PCR System BioRad CFX Opus 96 Real-time PCR System |
Opus O
Extraction reagens commendatur: RNeasy FFPE Kit (73504) ex QIAGEN, Paraffin Tissue Embedded Sectio Total RNA Extraction Kit(DP439) Tiangen Biotech (Beijing) Co.,Ltd.
