Mycobacterium Tuberculosis Isoniazid Resistentia Mutationis

Description:

Hoc ornamentum aptum est ad detectionem qualitativarum praecipuarum situum mutationis in sputo humano exemplorum e tuberculorum bacilli aegrorum positivorum collectorum, quae ad mycobacterium tuberculosis isoniazidorum resistentia ducunt: InhA promotor regionis -15C>T, -8T>A, -8T>C;AhpC fautor regionis -12C>T, -6G>A;homozygous mutatio KatG 315 codon 315G>A, 315G>C.

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Product nomen

HWTS-RT137 Mycobacterium Tuberculosis Isoniazid Resistentia Mutationis Detection Kit (Curva liquescens)

Epidemiologia

Mycobacterium tuberculosis, brevius sicut Tuberculus bacillus (TB), est bacterium pathogenicum quod tuberculosis causat.In statu, vulgo adhibita prima linea anti-tuberculosis medicamenta includunt isoniazid, rifampicin et hexambutolum, etc. Secunda linea anti-tuberculosis medicamenta includunt fluoroquinolones, amikacin et kanamycin, etc. Nova medicamenta evoluta sunt linezolida, bedaquilina et delamani, etc. Attamen, ex falso usu medicamentorum tuberculosis anti- quorum indolem structurae muri cellae mycobacterium tuberculosis, mycobacterium tuberculosis pharmaca resistentia in medicamentis anti-tuberculosis, quae graves provocationes ad praeventionis et curationem tuberculosis affert.

Channel

FAM	MP Acidi nuclei
ROX	Internum Imperium

Technical Parameters

Repono	≤-18℃
Fasciae vita	XII mensibus
Specimen Type	sputum
CV	≤5.0%
LoD	Modus deprehensio bacteria isoniazidarum silvestrium resistentium est 2x103 bacteria/mL, et modus deprehendendi bacteria mutantium est 2x103 bacteria/mL.
Specification	a.Nulla crux reactionem in genome humano, alia mycobacteria nontuberculoa et peripleumonia pathogens hoc ornamento deprehenditur. b.Mutatio situs aliorum medicamentorum resistentium generum in Mycobacterium tuberculosis typorum silvestrium, qualis resistentia determinantis regionis rifampicin gene rpoB, detectae sunt, et eventus experimentorum nullam resistentiam isoniazid demonstravit, nullam crucem reactivitatis indicans.
Applicabilis Instrumenta	SLAN-96P Real-time PCR Systems BioRad CFX96 Real-time PCR Systems LightCycler480® Real-time PCR System

Opus O

Si Macrone & Micro-teste Generali DNA/RNA Kit (HWTS-3019 utatur) (quod adhiberi potest cum Macro & Micro-test Automatico Nucleico Acido Extractor (HWTS-3006C, HWTS-3006B)) by Jiangsu Macro & Micro-Test Med-Tech Co., Ltd. pro extractione, adde 200μL potestate negativa et sputum processit specimen in ordine probatum, et adde 10 .μL imperium internum seorsum in potestatem negativam, processit sputum specimen probandum, et gradus subsequentes stricte peragi debent secundum instructiones extractionis.Extractum specimen volumen est 200μL, et volumen commendatur elutionis 100μL.